DMLE+: Bayesian linkage disequilibrium gene mapping

Bioinformatics. 2002 Jun;18(6):894-5. doi: 10.1093/bioinformatics/18.6.894.


Summary: The program DMLE+ allows Bayesian inference of the location of a gene carrying a mutation influencing a discrete trait (such as a disease) and/or other parameters of interest (such as mutation age) based on the observed linkage disequilibrium at multiple genetic markers. DMLE+ uses either individual marker genotypes, or haplotypes, integrates over uncertain population allele frequencies, and can incorporate prior information about gene location from an annotated human genome sequence.

Availability: DMLE+ is available in both Windows GUI and portable UNIX command line versions at

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bayes Theorem
  • Chromosome Mapping / statistics & numerical data*
  • Computational Biology
  • Genetic Markers
  • Genome, Human
  • Genotype
  • Haplotypes
  • Humans
  • Linkage Disequilibrium
  • Mutation
  • Probability
  • Software*


  • Genetic Markers