Relationship between serum magnesium levels and C-reactive protein concentration, in non-diabetic, non-hypertensive obese subjects

Int J Obes Relat Metab Disord. 2002 Apr;26(4):469-74. doi: 10.1038/sj.ijo.0801954.


Objective: To examine the association between serum magnesium levels and C-reactive protein (CRP) in non-diabetic, non-hypertensive obese subjects.

Design: Cross-sectional study.

Subjects: A total of 371 subjects, 101 men and 270 women. Of them 138 lean (37.2%), 133 (35.9%) overweight, and 100 (26.9%) were obese, matched by age.

Measurements: Fasting and 2 h serum glucose following a 75 g oral glucose load. Fasting serum total cholesterol, HDL- and LDL-cholesterol, triglycerides, C-reactive protein (CRP), albumin; and magnesium levels; urinary protein excretion; body mass index (BMI), waist-to-hip ratio (WHR), and blood pressure.

Results: The presence of CRP was documented in four (2.9%) lean, 13 (9.8%) overweight, and 20 (20.0%) obese subjects, and decreased magnesium levels (equal or less than 1.8 mg/dl), in 2 (1.45%) lean, 7 (5.2%) overweight, and 19 (19%) obese subjects. The lowest serum magnesium levels and the highest CRP concentrations were documented in the obese subjects. Twenty-three (82.1%) of the subjects with low serum magnesium (five overweight and 18 obese) showed CRP concentration equal or more than 10 mg/l. There was a graded significant decrease between CRP concentration and serum magnesium levels (r = -0.39, P = 0.002). The odds ratio (CI95%) between magnesium and CRP adjusted by age, sex, BMI and glucose tolerance status for the subjects within the low quartile of magnesium distribution was 2.11 (1.23-3.84).

Conclusion: The results of this study show that low serum magnesium levels are independently related to elevated CRP concentration, in non-diabetic, non-hypertensive obese subjects.

MeSH terms

  • Adult
  • Blood Glucose / analysis
  • Body Constitution
  • Body Mass Index
  • C-Reactive Protein / analysis*
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Fasting
  • Female
  • Glucose Tolerance Test
  • Humans
  • Magnesium / blood*
  • Male
  • Middle Aged
  • Obesity / blood*
  • Obesity / urine
  • Odds Ratio
  • Proteinuria
  • Triglycerides / blood


  • Blood Glucose
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Triglycerides
  • C-Reactive Protein
  • Cholesterol
  • Magnesium