Fatigue during high-intensity intermittent exercise: application to bodybuilding

Sports Med. 2002;32(8):511-22. doi: 10.2165/00007256-200232080-00003.


Resistance exercise is an activity performed by individuals interested in competition, those who wish to improve muscle mass and strength for other sports, and for individuals interested in improving their strength and physical appearance. In this review we present information suggesting that phosphocreatine depletion, intramuscular acidosis and carbohydrate depletion are all potential causes of the fatigue during resistance exercise. In addition, recommendations are provided for nutritional interventions, which might delay muscle fatigue during this type of activity.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acid-Base Equilibrium / physiology
  • Carbohydrate Metabolism
  • Creatine / administration & dosage
  • Dietary Supplements
  • Exercise / physiology*
  • Glycogen / metabolism
  • Humans
  • Muscle Fatigue / physiology*
  • Muscle, Skeletal / metabolism
  • Muscle, Skeletal / physiology*
  • Weight Lifting / physiology*


  • Glycogen
  • Creatine