ML -- a conserved domain involved in innate immunity and lipid metabolism

Trends Biochem Sci. 2002 May;27(5):219-21. doi: 10.1016/s0968-0004(02)02084-4.


ML (MD-2-related lipid-recognition) is a novel domain identified in MD-1, MD-2, GM2A, Npc2 and multiple proteins of unknown function in plants, animals and fungi. These single-domain proteins were predicted to form a beta-rich fold containing multiple strands, and to mediate diverse biological functions through interacting with specific lipids.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, Surface / chemistry
  • Antigens, Surface / genetics
  • Antigens, Surface / metabolism*
  • Humans
  • Immunity, Innate*
  • Lipid Metabolism*
  • Lipopolysaccharides / immunology
  • Lipopolysaccharides / metabolism
  • Molecular Sequence Data
  • Protein Structure, Tertiary
  • Sequence Alignment
  • Signal Transduction / physiology


  • Antigens, Surface
  • LY86 protein, human
  • Lipopolysaccharides