Viral RNA-polymerases -- a predicted 2'-O-ribose methyltransferase domain shared by all Mononegavirales

Trends Biochem Sci. 2002 May;27(5):222-4. doi: 10.1016/s0968-0004(02)02091-1.


The Mononegavirales virus group comprises several major human pathogens, including measles, rabies and Ebola viruses. This article reports a computational analysis of the C-terminal region of RNA-dependent RNA-polymerases from Mononegavirales. Using a combination of sequence similarity and threading analysis, a 2'-O-ribose methyltransferase domain was identified that is involved in the capping of viral mRNAs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • DNA-Directed RNA Polymerases / chemistry*
  • DNA-Directed RNA Polymerases / genetics*
  • DNA-Directed RNA Polymerases / metabolism
  • Humans
  • Methyltransferases / chemistry*
  • Methyltransferases / genetics*
  • Methyltransferases / metabolism
  • Molecular Sequence Data
  • Mononegavirales / enzymology*
  • Mononegavirales / genetics
  • Protein Structure, Tertiary
  • RNA Caps / metabolism*
  • RNA Processing, Post-Transcriptional*
  • RNA, Viral / metabolism
  • Sequence Alignment


  • RNA Caps
  • RNA, Viral
  • Methyltransferases
  • DNA-Directed RNA Polymerases