Review
doi: 10.1126/science.1070963.
Unique chromatin remodeling and transcriptional regulation in spermatogenesis
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- PMID: 12077401
- DOI: 10.1126/science.1070963
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Review
Unique chromatin remodeling and transcriptional regulation in spermatogenesis
Science.
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Abstract
Most of our knowledge of transcriptional regulation comes from studies in somatic cells. However, increasing evidence reveals that gene regulation mechanisms are different in haploid germ cells. A number of highly specialized strategies operate during spermatogenesis. These include a unique chromatin reorganization program and the use of distinct promoter elements and specific transcription factors. Deciphering the rules governing transcriptional control during spermatogenesis will provide valuable insights of biomedical importance.
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