Synthesis and DNA-binding properties of cationic 2,2':6',2' '-terpyridineplatinum(II) complexes containing 1,2- and 1,7-dicarba-closo-dodecaborane(12)

Inorg Chem. 2002 Jul 1;41(13):3331-3. doi: 10.1021/ic025536v.

Abstract

The first examples of DNA metallointercalators containing a dicarba-closo-dodecaborane(12) (carborane) moiety are presented. Treatment of the labile platinum(II) complex [Pt(OTf)(terpy)](+) (terpy = 2,2':6',2' '-terpyridine) with the 1,2-carborane monothiol derivatives 1-HS(CH(2))(n)-1,2-C(2)B(10)H(11) (n = 0, 1) or the novel 1,7-carborane ligand, 1-HSCH(2)-1,7-C(2)B(10)H(11), affords the stable, brightly colored species [Pt(1-S(CH(2))(n)-1,Z-C(2)B(10)H(11))(terpy)](+) (Z = 2, n = 0, 1; Z = 7, n = 1) in good yield and purity. Preliminary DNA-binding experiments with calf-thymus DNA indicate an intercalative interaction by the platinum(II) complexes at high r(f) values.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Boron Compounds / chemistry*
  • Boron Compounds / metabolism*
  • Boron Neutron Capture Therapy
  • Cattle
  • Cross-Linking Reagents / chemistry
  • Cross-Linking Reagents / metabolism
  • DNA / metabolism*
  • Drug Design*
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Molecular Structure
  • Organoplatinum Compounds / chemistry*
  • Organoplatinum Compounds / metabolism*
  • Thymus Gland
  • Zinc / chemistry

Substances

  • Boron Compounds
  • Cross-Linking Reagents
  • Organoplatinum Compounds
  • DNA
  • Zinc