[Anti-GQ1b IgG-negative case of overlapping Fisher's and Gullain-Barré syndromes after Campylobacter jejuni (PEN 19) enteritis]

Rinsho Shinkeigaku. 2001 Nov;41(11):801-4.
[Article in Japanese]


We described a 70-year-old woman with overlapping Fisher's syndrome (FS) and Guillain-Barré syndrome (GBS), from whom Campylobacter jejuni had been isolated. In typical FS as well as GBS with ophthalmoplegia and acute ophthalmoparesis without ataxia, serum anti-GQ1b IgG antibody often is detected and ophthalmoplegia is characterized by the predominant abducens palsy. This patient, however, showed marked oculomotor nerve disturbance. Serum anti-GQ1b IgG antibody was negative and IgG antibodies against GM1, GM1b, and GD1a were strongly positive. Although FS and overlap of FS/GBS have been reported to be associated with PEN2 of C. jejuni, the isolate from our case belonged to PEN 19. C. jejuni serotype may be associated with clinical manifestations and anti-ganglioside antibody species.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Campylobacter Infections / complications*
  • Campylobacter jejuni*
  • Female
  • Gangliosides / immunology*
  • Guillain-Barre Syndrome / complications*
  • Guillain-Barre Syndrome / immunology
  • Humans
  • Immunoglobulin G / analysis
  • Miller Fisher Syndrome / complications*
  • Miller Fisher Syndrome / immunology


  • Gangliosides
  • Immunoglobulin G
  • GQ1b ganglioside