Nobiletin as a tyrosinase inhibitor from the peel of Citrus fruit

Biol Pharm Bull. 2002 Jun;25(6):806-8. doi: 10.1248/bpb.25.806.

Abstract

A tyrosinase inhibitor was isolated from the peel of Citrus fruit by activity-guided fractionation, and identified as 3',4',5,6,7,8-hexamethoxyflavone (nobiletin) by comparison with reported spectral data. Nobiletin (IC50 of; 46.2 microM) exhibited more potency than Kojic acid (IC50; 77.4 microM) used as a positive control, and it was found to be potentially an effective inhibitor of the production of melanin.

MeSH terms

  • Agaricales / enzymology
  • Citrus / chemistry*
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology*
  • Flavones*
  • Flavonoids / isolation & purification
  • Flavonoids / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Melanins / biosynthesis
  • Monophenol Monooxygenase / antagonists & inhibitors*
  • Pyrones / pharmacology
  • Spectrophotometry, Infrared
  • Spectroscopy, Fourier Transform Infrared

Substances

  • Enzyme Inhibitors
  • Flavones
  • Flavonoids
  • Melanins
  • Pyrones
  • kojic acid
  • nobiletin
  • Monophenol Monooxygenase