Abstract
A tyrosinase inhibitor was isolated from the peel of Citrus fruit by activity-guided fractionation, and identified as 3',4',5,6,7,8-hexamethoxyflavone (nobiletin) by comparison with reported spectral data. Nobiletin (IC50 of; 46.2 microM) exhibited more potency than Kojic acid (IC50; 77.4 microM) used as a positive control, and it was found to be potentially an effective inhibitor of the production of melanin.
MeSH terms
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Agaricales / enzymology
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Citrus / chemistry*
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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Flavones*
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Flavonoids / isolation & purification
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Flavonoids / pharmacology*
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Magnetic Resonance Spectroscopy
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Melanins / biosynthesis
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Monophenol Monooxygenase / antagonists & inhibitors*
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Pyrones / pharmacology
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Spectrophotometry, Infrared
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Spectroscopy, Fourier Transform Infrared
Substances
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Enzyme Inhibitors
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Flavones
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Flavonoids
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Melanins
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Pyrones
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kojic acid
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nobiletin
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Monophenol Monooxygenase