Abstract
Tissue-engineered primary adult sheep muscle cells genetically engineered to express either rhVEGF or rhIGF-1 secreted the bioactive proteins locally in the sheep heart for at least 30 days.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Biocompatible Materials*
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Endothelial Growth Factors / biosynthesis
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Endothelial Growth Factors / genetics
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Genetic Therapy / methods
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Immunohistochemistry
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Insulin-Like Growth Factor I / biosynthesis
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Insulin-Like Growth Factor I / genetics
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Lymphokines / biosynthesis
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Lymphokines / genetics
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Muscle, Skeletal / cytology
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Muscles / cytology*
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Myocardium / cytology*
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Neovascularization, Physiologic
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Recombinant Proteins / metabolism
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Sheep
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Time Factors
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Vascular Endothelial Growth Factor A
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Vascular Endothelial Growth Factors
Substances
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Biocompatible Materials
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Endothelial Growth Factors
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Lymphokines
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Recombinant Proteins
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Vascular Endothelial Growth Factor A
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Vascular Endothelial Growth Factors
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Insulin-Like Growth Factor I