Xwnt-2 (Xwnt-2b) is maternally expressed in Xenopus oocytes and embryos

Biochim Biophys Acta. 2002 Jul 19;1576(3):265-8. doi: 10.1016/s0167-4781(02)00344-5.


Xwnt-2 (formerly Xwnt-2b) is a member of the Xwnt-8 class of axis-inducing Wnts. Its zygotic expression is at the prosencephalic-mesencephalic border of the early tadpole brain and above the heart primordium [Mech. Dev. 63 (1997) 199]. Here, we report that Xwnt-2 has an earlier, maternal pattern of expression. It is detected in the oocyte, egg and the developing embryo. Studies of the spatial localization of maternal Xwnt-2 show transcripts in both vegetal and animal blastomeres with enrichment in the animal hemisphere. The identification of maternal Xwnt-2 raises questions about possible roles of dorsalizing Xwnts in axial patterning of the Xenopus embryo.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Body Patterning
  • Embryo, Nonmammalian / metabolism
  • Female
  • Glycoproteins / genetics
  • Glycoproteins / metabolism*
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism*
  • Oocytes / physiology*
  • RNA / metabolism
  • Tissue Distribution
  • Wnt2 Protein
  • Xenopus Proteins / genetics
  • Xenopus Proteins / metabolism*
  • Xenopus laevis / embryology*
  • Xenopus laevis / physiology


  • Glycoproteins
  • Nerve Tissue Proteins
  • WNT2B protein, Xenopus
  • Wnt2 Protein
  • Xenopus Proteins
  • RNA