Nontherapeutic research with children: Grimes v Kennedy Krieger Institute

Am J Public Health. 2002 Jul;92(7):1070-3. doi: 10.2105/ajph.92.7.1070.


Research with young children raises difficult issues of law and ethics. A recent Maryland case, Grimes v Kennedy Krieger Institute, Inc, appears to impose restrictive rules on research with children when the subjects are put at risk but cannot derive direct benefit from their involvement in the research project. This case exemplifies the tension that exists between the goal of science to increase knowledge and the protection of the rights and welfare of nonconsenting research subjects. While some language in the opinion may be difficult to understand or apply, for the most part the case reflects the problems other courts and ethicists have had in delineating the role of children in "nontherapeutic" research.

Publication types

  • Legal Case

MeSH terms

  • Child
  • Child Advocacy / legislation & jurisprudence*
  • Clinical Trials as Topic / legislation & jurisprudence*
  • Ethics*
  • Human Experimentation / legislation & jurisprudence*
  • Humans
  • Lead / adverse effects
  • Lead / analysis
  • Maryland
  • Moral Obligations
  • Public Health / legislation & jurisprudence*
  • Public Health / standards
  • Public Housing
  • Risk
  • Third-Party Consent / legislation & jurisprudence*


  • Lead