Somatic glypican 3 (GPC3) mutations in Wilms' tumour

Br J Cancer. 2002 Jun 17;86(12):1920-2. doi: 10.1038/sj.bjc.6600417.


Tumour and normal tissue from 41 male cases of Wilms' tumour were screened to determine the presence of sequence variants in the glypican 3 (GPC3) gene. Two non-conservative single base changes were present in tumour tissue only. These findings imply a possible role for GPC3 in Wilms' tumour development.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA Primers / chemistry
  • Glypicans
  • Heparan Sulfate Proteoglycans / genetics*
  • Humans
  • Kidney Neoplasms / genetics*
  • Male
  • Mutation / genetics*
  • Polymerase Chain Reaction
  • Polymorphism, Single-Stranded Conformational
  • Wilms Tumor / genetics*


  • DNA Primers
  • Glypicans
  • Heparan Sulfate Proteoglycans