Integrins and prostate cancer metastases

Cancer Metastasis Rev. 2001;20(3-4):321-31. doi: 10.1023/a:1015547830323.


Integrins have emerged as modulators of a variety of cellular functions. They have been implicated in cell migration, survival, normal and aberrant cellular growth, differentiation, gene expression, and modulation of intracellular signal transduction pathways. In this review article, the structural and functional characteristics of integrins, their expression and their potential role in prostate cancer metastases will be discussed.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenocarcinoma / metabolism*
  • Adenocarcinoma / pathology
  • Cell Movement / physiology
  • Humans
  • Integrins / physiology*
  • Male
  • Neoplasm Metastasis
  • Neoplasm Proteins / physiology*
  • Prostatic Neoplasms / metabolism*
  • Prostatic Neoplasms / pathology
  • Signal Transduction / physiology


  • Integrins
  • Neoplasm Proteins