BB rat lyp mutation and Type 1 diabetes

Immunol Rev. 2001 Dec;184:161-71. doi: 10.1034/j.1600-065x.2001.1840115.x.

Abstract

BioBreeding (BB) rats spontaneously develop an autoimmune diabetic syndrome similar to that observed in humans and NOD mice. One of the diabetes susceptibility loci maps to the lyp locus on chromosome 4. In this article we describe the consequences of the BB rat lyp mutation on T-cell homeostasis, repertoire and function, as well as its role in the pathogenesis of type I diabetes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 1 / genetics*
  • Diabetes Mellitus, Type 1 / immunology
  • Humans
  • Lymphopenia / immunology
  • Lymphopenia / physiopathology
  • Mice
  • Mitosis
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • Protein Tyrosine Phosphatase, Non-Receptor Type 22
  • Protein Tyrosine Phosphatases / genetics*
  • Rats
  • Rats, Mutant Strains / genetics*
  • Rats, Mutant Strains / immunology
  • T-Lymphocytes / immunology

Substances

  • PTPN22 protein, human
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • Protein Tyrosine Phosphatase, Non-Receptor Type 22
  • Protein Tyrosine Phosphatases
  • Ptpn22 protein, mouse