Thymic development and repertoire selection: the rat perspective

T Hünig; N Torres-Nagel; B Mehling; H J Park; T Herrmann

doi:10.1034/j.1600-065x.2001.1840102.x

Thymic development and repertoire selection: the rat perspective

Immunol Rev. 2001 Dec:184:7-19. doi: 10.1034/j.1600-065x.2001.1840102.x.

Authors

T Hünig¹, N Torres-Nagel, B Mehling, H J Park, T Herrmann

Affiliation

¹ Institute for Virology and Immunobiology, University of Würzburg, Germany. huenig@vim.uni-wuerzburg.de

PMID: 12086323
DOI: 10.1034/j.1600-065x.2001.1840102.x

Abstract

This review summarizes our current knowledge of T-cell maturation and repertoire selection in the rat thymus. Some unique features of early thymocyte development and of CD4/CD8 lineage decision are described. A detailed analysis of lineage progression through the CD4, CD8 "double positive" compartment and T-cell receptor-induced CD8 T-cell maturation in cell culture is provided. A second emphasis is placed on interactions between germline-encoded T-cell receptor elements with MHC molecules in thymic repertoire selection and alloreactivity

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
CD4-Positive T-Lymphocytes / cytology*
CD4-Positive T-Lymphocytes / immunology
CD8-Positive T-Lymphocytes / cytology*
CD8-Positive T-Lymphocytes / immunology
Cell Differentiation
Humans
Major Histocompatibility Complex
Rats
Receptors, Antigen, T-Cell* / genetics
Receptors, Antigen, T-Cell, alpha-beta / genetics
Receptors, Interleukin-2
Thymus Gland / cytology*
Thymus Gland / immunology

Substances

Receptors, Antigen, T-Cell
Receptors, Antigen, T-Cell, alpha-beta
Receptors, Interleukin-2