Sex, AGility, and the regulation of alternative splicing

Cell. 2002 May 17;109(4):409-12. doi: 10.1016/s0092-8674(02)00750-x.


Alternative splicing is an important means of regulating the expression of eukaryotic genes and enhancing protein diversity. A detailed examination of the Drosophila Sex-lethal gene has led to two significant discoveries-the role of the splicing factor SPF45 in defining the site of exon ligation, and that alternative splicing can be regulated at the second step.

Publication types

  • Review

MeSH terms

  • Alternative Splicing / genetics*
  • Animals
  • Drosophila Proteins*
  • Eukaryotic Cells / cytology
  • Eukaryotic Cells / metabolism*
  • Gene Expression Regulation / genetics*
  • Humans
  • Mutation / genetics
  • RNA Splicing Factors
  • RNA, Messenger / genetics*
  • RNA-Binding Proteins / genetics
  • Sex Determination Processes


  • Drosophila Proteins
  • RBM17 protein, human
  • RNA Splicing Factors
  • RNA, Messenger
  • RNA-Binding Proteins
  • Sxl protein, Drosophila