Jekyll-Hyde neurotrophins: the story of proNGF

Trends Neurosci. 2002 Jun;25(6):284-6. doi: 10.1016/s0166-2236(02)02169-0.


Neurotrophins promote neuronal survival and differentiation by binding to two classes of cell surface receptors: members of the Trk-family receptor tyrosine kinases and p75(NTR), a member of the tumor necrosis factor receptor superfamily. The discoveries that the unprocessed proneurotrophin peptide is both a preferential high-affinity ligand for p75(NTR) (with minimal affinity for trkA) and a potent inducer of p75(NTR)-mediated neuronal cell death are likely to change our understanding of neurotrophin physiology and our ability to manipulate their signaling pathways.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Death
  • Nerve Growth Factor / metabolism*
  • Nerve Growth Factors / metabolism
  • Protein Precursors / metabolism*
  • Receptor, Nerve Growth Factor
  • Receptor, trkA / agonists
  • Receptors, Nerve Growth Factor / agonists*


  • Nerve Growth Factors
  • Protein Precursors
  • Receptor, Nerve Growth Factor
  • Receptors, Nerve Growth Factor
  • pro-nerve growth factor, human
  • Nerve Growth Factor
  • Receptor, trkA