A matter of life and death

Cancer Cell. 2002 Feb;1(1):19-30. doi: 10.1016/s1535-6108(02)00024-7.


We propose that deregulation of proliferation, together with a reduction in apoptosis, creates a platform that is both necessary and can be sufficient for cancer. The secondary traits of diverse neoplasms are a consequence of cell proliferation, tissue expansion, and other outcomes of this platform.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis*
  • Cell Division
  • Cell Survival
  • Humans
  • Neoplasms / pathology*
  • Signal Transduction