Cancer Genomics

Cancer Cell. 2002 Feb;1(1):37-47. doi: 10.1016/s1535-6108(02)00026-0.

Abstract

The draft human genome sequence and the dissemination of high throughput technology provides opportunities for systematic analysis of cancer cells. Genome-wide mutation screens, high resolution analysis of chromosomal abberations and expression profiling all give comprehensive views of genetic alterations in cancer cells. From these analyses will come a complete list of the genetic changes that drive malignant transformation and of the therapeutic targets that may be exploited for clinical benefit.

Publication types

  • Review

MeSH terms

  • Cell Transformation, Neoplastic / genetics
  • Chromosome Aberrations
  • Genomics
  • Humans
  • Neoplasms / genetics*
  • Neoplasms / therapy
  • Transformation, Genetic