Concomitant risk factors in reports of torsades de pointes associated with macrolide use: review of the United States Food and Drug Administration Adverse Event Reporting System

Clin Infect Dis. 2002 Jul 15;35(2):197-200. doi: 10.1086/340861. Epub 2002 Jun 19.


In this case series, we examined concomitant risk factors mentioned in reports of torsades de pointes, a rare ventricular arrhythmia, that occurred in association with administration of macrolide antimicrobials (e.g., azithromycin, clarithromycin, dirithromycin, and erythromycin). Increasing age, female sex, and concomitant diseases and drug administration believed to increase risks for torsades de pointes were commonly reported.

Publication types

  • Review

MeSH terms

  • Adverse Drug Reaction Reporting Systems*
  • Age Factors
  • Anti-Bacterial Agents / adverse effects*
  • Anti-Bacterial Agents / therapeutic use
  • Comorbidity
  • Drug Therapy, Combination
  • Electrocardiography
  • Female
  • Humans
  • Macrolides
  • Male
  • Middle Aged
  • Retrospective Studies
  • Risk Factors
  • Sex Factors
  • Torsades de Pointes / chemically induced*
  • Torsades de Pointes / epidemiology
  • Torsades de Pointes / physiopathology


  • Anti-Bacterial Agents
  • Macrolides