A carcinosarcoma/sarcomatoid carcinoma arising in a urinary bladder diverticulum

Arch Pathol Lab Med. 2002 Jul;126(7):853-5. doi: 10.5858/2002-126-0853-ACSCAI.

Abstract

We describe an invasive polypoid carcinosarcoma/sarcomatoid carcinoma arising within a urinary bladder diverticulum in a 65-year-old patient with synchronous, moderately differentiated prostatic adenocarcinoma. Histologically, the diverticular tumor exhibits an admixture of different morphologic components, including invasive high-grade urothelial carcinoma, malignant glandular structures in a cellular background of malignant spindle cells, and areas formed exclusively by spindle and pleomorphic cells. There was full-thickness involvement of the diverticulum with extension of the tumor into the perivesical fat and ipsilateral seminal vesicle. In view of the early invasive behavior of carcinosarcoma/sarcomatoid carcinoma combined with the paucity of the muscular layer in the diverticulum wall, a graver prognosis was expected for this aggressive tumor that occurred in this unusual site.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / chemistry
  • Adenocarcinoma / pathology
  • Adenocarcinoma / surgery
  • Aged
  • Biomarkers, Tumor / analysis
  • Carcinosarcoma / chemistry
  • Carcinosarcoma / pathology*
  • Carcinosarcoma / surgery
  • Diverticulum / metabolism
  • Diverticulum / pathology*
  • Diverticulum / surgery
  • Fatal Outcome
  • Humans
  • Male
  • Neoplasms, Multiple Primary
  • Prostatic Neoplasms / chemistry
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / surgery
  • Urinary Bladder / chemistry
  • Urinary Bladder / pathology*
  • Urinary Bladder / surgery
  • Urinary Bladder Neoplasms / chemistry
  • Urinary Bladder Neoplasms / pathology*
  • Urinary Bladder Neoplasms / surgery

Substances

  • Biomarkers, Tumor