Links between innate and adaptive immunity via type I interferon

Curr Opin Immunol. 2002 Aug;14(4):432-6. doi: 10.1016/s0952-7915(02)00354-0.


Type I interferon (IFN-alpha/beta) is expressed rapidly following exposure to a wide variety of infectious agents and plays a key role in innate control of virus replication. Recent studies have demonstrated that dendritic cells both produce IFN-alpha/beta and undergo maturation in response to IFN-alpha/beta. Moreover, IFN-alpha/beta has been shown to potently enhance immune responses in vivo through the stimulation of dendritic cells. These findings indicate that IFN-alpha/beta serves as a signal linking innate and adaptive immunity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adjuvants, Immunologic / physiology
  • Animals
  • Dendritic Cells / immunology*
  • Humans
  • Immunity, Innate
  • Infections / immunology*
  • Interferon Type I / physiology*
  • Lymphocyte Activation
  • Models, Immunological


  • Adjuvants, Immunologic
  • Interferon Type I