T cell immunity in lymphoid and non-lymphoid tissues

Curr Opin Immunol. 2002 Aug;14(4):503-8. doi: 10.1016/s0952-7915(02)00360-6.


Immune responses to infection or effective vaccination generally result in the development of memory lymphocytes capable of mounting a rapid response to secondary infection. Since most infections initiate in non-lymphoid tissues, defense at these sites may be important for protection. Recent results suggest that a substantial portion of the T cell response to infection is focused in non-lymphoid tissues. Furthermore, anatomic localization appears to define phenotypic and functional heterogeneity among antigen-specific memory T cell populations.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Movement
  • Immunity, Cellular
  • Immunologic Memory
  • Infections / immunology
  • Lymphoid Tissue / immunology*
  • Models, Immunological
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocytes / immunology*