NK cell receptors in antiviral immunity

Curr Opin Immunol. 2002 Aug;14(4):509-16. doi: 10.1016/s0952-7915(02)00357-6.


An array of inhibitory and activating receptors initially identified on NK cells are also expressed by conventional CD8+ alphabeta T cells. New evidence strongly implicates these 'NK cell receptors' in modulating NK cell and virus-specific CD8+ T cell responses against a variety of viral infections. Precise regulation of NK cell and T cell responses by these receptors optimizes antiviral immunity while preventing immunological bystander pathology and autoimmunity.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Immunity, Cellular
  • Killer Cells, Natural / immunology*
  • Mice
  • Models, Immunological
  • Receptors, Immunologic / physiology*
  • Receptors, KIR
  • T-Lymphocytes, Cytotoxic / immunology*
  • Virus Diseases / immunology*
  • Viruses / pathogenicity


  • Receptors, Immunologic
  • Receptors, KIR