Influence of congenital heart disease on survival in children with congenital diaphragmatic hernia

J Pediatr. 2002 Jul;141(1):25-30. doi: 10.1067/mpd.2002.125004.


Objective: We sought to assess outcome in patients with CDH and HD to determine if LHR is also predictive of outcome in this subset of patients.

Study design: We carried out a retrospective review (April 1996-October 2000) of patients with isolated CDH (n = 143, 82.2%) and patients with HD (n = 31, 17.8%) to determine the incidence of additional anomalies, survival to term, CDH repair, cardiac repair, and survival to discharge. Survival based on LHR was analyzed in a subset of fetuses.

Results: The risk of death from birth to last follow-up was 2.9 times higher for patients with CDH plus HD than for patients with CDH alone (P <.0001). Of 11 patients with CDH plus HD who had CDH repair (5 of whom also had HD repair), 5 survived. All 10 patients with an LHR <1.2 died; 3 of 6 with an LHR >1.2 survived (Fisher exact test, P =.04).

Conclusion: Heart disease remains a significant risk factor for death in infants with CDH. The LHR helps predict survival in this high-risk group of patients.

MeSH terms

  • Abnormalities, Multiple / mortality*
  • Female
  • Heart Defects, Congenital*
  • Hernia, Diaphragmatic / diagnostic imaging
  • Hernia, Diaphragmatic / mortality*
  • Hernias, Diaphragmatic, Congenital*
  • Humans
  • Infant, Newborn
  • Lung / pathology
  • Pennsylvania / epidemiology
  • Pregnancy
  • Proportional Hazards Models
  • Retrospective Studies
  • Risk
  • Survival Rate
  • Ultrasonography, Prenatal