Persistent hyperlipasemia caused by macrolipase in an adolescent

J Pediatr. 2002 Jul;141(1):129-31. doi: 10.1067/mpd.2002.124591.


Serum amylase and lipase frequently rise during bouts of acute pancreatitis, and measurement of these enzymes provides important diagnostic information. We report a pediatric patient with persistent elevations of serum lipase resulting from macrolipasemia, a complex of lipase with IgG, rather than pancreatitis.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Adolescent
  • Diagnosis, Differential
  • Female
  • Humans
  • Immunoglobulin G / blood*
  • Immunologic Techniques
  • Lipase / blood*
  • Lipase / immunology*
  • Macromolecular Substances
  • Metabolic Diseases / diagnosis*
  • Pancreatitis / diagnosis


  • Immunoglobulin G
  • Macromolecular Substances
  • Lipase