Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy

Nat Med. 2002 Jul;8(7):673-80. doi: 10.1038/nm0702-673.


Adequate control of HIV requires impairing the infection, replication and spread of the virus, no small task given the extraordinary capacity of HIV to exploit the cell's molecular machinery in the course of infection. Understanding the dynamic interplay of host cell and virus is essential to the effort to eradicate HIV.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acquired Immunodeficiency Syndrome / drug therapy
  • Acquired Immunodeficiency Syndrome / physiopathology*
  • Cells / ultrastructure
  • Cells / virology*
  • HIV / pathogenicity
  • HIV / physiology*
  • HIV Infections / drug therapy
  • HIV Infections / physiopathology*
  • Humans
  • Nuclear Pore / virology
  • Virus Replication