Organogenesis: molecular mechanisms of tubulogenesis

Nat Rev Genet. 2002 Jul;3(7):513-23. doi: 10.1038/nrg840.


As organisms have evolved in size and complexity, tubular systems have developed to enable the efficient transport of substances into and out of tissues. These tubular systems are generated using strategies that are based on common elements of cell behaviour, including cell polarization, tube migration to target sites, cell-fate diversification and localization of specialized cells to different regions of the tube system. Using examples from both invertebrate and vertebrate systems, this review highlights progress in understanding these basic principles and briefly discusses the possible evolution of strategies to regulate the morphogenesis of tubular systems.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Physiological Phenomena
  • Cell Polarity
  • Embryonic and Fetal Development / physiology*
  • Humans
  • Neovascularization, Physiologic