The Phosphatidylinositol 3-Kinase AKT Pathway in Human Cancer

Nat Rev Cancer. 2002 Jul;2(7):489-501. doi: 10.1038/nrc839.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Division
  • Disease Models, Animal
  • Gene Deletion
  • Humans
  • Lipids
  • Mice
  • Models, Biological
  • Neoplasms / enzymology*
  • Phenotype
  • Phosphatidylinositol 3-Kinases / metabolism
  • Phosphatidylinositol 3-Kinases / physiology*
  • Phosphatidylinositol Phosphates / physiology
  • Protein Biosynthesis
  • Protein-Serine-Threonine Kinases*
  • Proto-Oncogene Proteins / metabolism*
  • Proto-Oncogene Proteins c-akt
  • Signal Transduction*

Substances

  • Lipids
  • Phosphatidylinositol Phosphates
  • Proto-Oncogene Proteins
  • phosphatidylinositol 3,4,5-triphosphate
  • Phosphatidylinositol 3-Kinases
  • AKT1 protein, human
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt