Chemoprevention: an essential approach to controlling cancer

Nat Rev Cancer. 2002 Jul;2(7):537-43. doi: 10.1038/nrc844.


Mortality that results from the common forms of cancer is still unacceptably high. Despite immense advances in the understanding of the mechanisms of carcinogenesis, in bringing potent new drugs to the clinic and in treating several relatively rare forms of cancer, overall mortality statistics are unlikely to change in a fundamental way until there has been a re-orientation of emphasis in cancer research that will direct greater resources towards prevention of new disease, rather than treatment of end-stage disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Female
  • Humans
  • Male
  • Models, Biological
  • Models, Chemical
  • Neoplasms / mortality
  • Neoplasms / prevention & control*
  • Neoplasms / therapy*
  • Signal Transduction
  • Time Factors