Ferulagone: a new monoterpene ester from Ferulago thirkeana essential oil

Planta Med. 2002 Jun;68(6):564-7. doi: 10.1055/s-2002-32557.

Abstract

Essential oil obtained by micro-distillation and hydrodistillation of the endemic Ferulago thirkeana (Boiss.) Boiss. (Apiaceae) was analysed by GC/MS. An unknown component isolated from the essential oil was characterized by chromato-spectral techniques (1D-, 2D-NMR, HRMS, IR and UV) as (1 S)-2,6,6-trimethyl-4-oxobicyclo[3.1.1]hept-2-enyl(2 E)-2-methylbut-2-enoate (= ferulagone or 1-angeloyloxyverbenone) (1). Biological activities of the essential oil and the purified major component (1) were tested against various human pathogenic microorganisms resulting in moderate inhibition (62.5 - 125 microg/ml).

Publication types

  • Letter

MeSH terms

  • Apiaceae*
  • Bacteria / drug effects
  • Candida albicans / drug effects
  • Gas Chromatography-Mass Spectrometry
  • Oils, Volatile / chemistry
  • Oils, Volatile / isolation & purification
  • Oils, Volatile / pharmacology
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Terpenes / chemistry
  • Terpenes / isolation & purification
  • Terpenes / pharmacology*

Substances

  • Oils, Volatile
  • Plant Extracts
  • Terpenes
  • ferulagone