Expression of NM23 and tenascin in invasive ductal carcinomas of the breast

Eur J Gynaecol Oncol. 2002;23(3):261-3.

Abstract

Objective: In this series of ductal carcinoma of the breast, immunoexpression of antimetastasis gene nm23 and tenascin was examined and the role in prognosis was investigated by correlation with the tumour grade and stage, and ER/PR immunoexpression.

Material and methods: In this study 27 ductal carcinomas of the breast were analysed for expression of tenascin and nm23 antimetastasis genes by immunohistochemistry.

Results: The results of our study revealed a statistically significant correlation between nm23-H1 immunoexpression and lymph node metastasis. We also found a statistically significant correlation between tenascin and nm23-H1 immunoexpression. Our results suggest that tenascin limits tumour spread.

Conclusion(s): Antimetastasis gene expression can be used in predicting lymph node metastasis in ductal carcinomas of the breast.

MeSH terms

  • Adult
  • Aged
  • Biomarkers, Tumor / metabolism*
  • Breast Neoplasms / metabolism*
  • Breast Neoplasms / pathology
  • Carcinoma, Ductal, Breast / metabolism*
  • Carcinoma, Ductal, Breast / pathology
  • Female
  • Humans
  • Immunohistochemistry
  • Lymphatic Metastasis / diagnosis
  • Middle Aged
  • Monomeric GTP-Binding Proteins / metabolism*
  • NM23 Nucleoside Diphosphate Kinases
  • Neoplasm Staging
  • Nucleoside-Diphosphate Kinase*
  • Prognosis
  • Tenascin / metabolism*
  • Transcription Factors / metabolism*

Substances

  • Biomarkers, Tumor
  • NM23 Nucleoside Diphosphate Kinases
  • Tenascin
  • Transcription Factors
  • NME1 protein, human
  • Nucleoside-Diphosphate Kinase
  • Monomeric GTP-Binding Proteins