Myofascial pain syndrome and its suggested role in the pathogenesis and treatment of fibromyalgia syndrome

Curr Pain Headache Rep. 2002 Aug;6(4):274-83. doi: 10.1007/s11916-002-0048-z.


Myofascial pain syndrome is a chronic muscle pain disorder in one or more muscles or groups of muscles accompanied by local and referred pain, decreased range of motion, weakness, and often autonomic phenomena. Patients are readily recognized by their history of muscle pain and the presence of myofascial trigger points, which are specific areas of hyperirritability in a muscle that cause local and referred pain on palpation. Failure to recognize MPS often leads to over-investigation, unnecessary medical intervention, and iatrogenic harm with serious cost implications. The purpose of this review is to present clinically relevant data regarding myofascial pain syndrome and to discuss its possible role in the pathophysiology and optimal treatment of fibromyalgia syndrome.

Publication types

  • Review

MeSH terms

  • Autonomic Nervous System / physiopathology
  • Central Nervous System / physiopathology
  • Combined Modality Therapy
  • Diagnosis, Differential
  • Fibromyalgia / diagnosis
  • Fibromyalgia / physiopathology*
  • Fibromyalgia / therapy
  • Humans
  • Muscle, Skeletal / innervation
  • Myofascial Pain Syndromes / diagnosis
  • Myofascial Pain Syndromes / physiopathology*
  • Myofascial Pain Syndromes / therapy
  • Nociceptors / physiopathology
  • Patient Care Team