Microanatomical localization of PD-1 in human tonsils

Immunol Lett. 2002 Oct 1;83(3):215-20. doi: 10.1016/s0165-2478(02)00088-3.


PD-1 is an immunoinhibitory receptor, which belongs structurally to the CD28 family. PD-1-deficient mice show breakdown of peripheral tolerance and manifest multiple autoimmune symptoms. We previously described expression of PD-1 on activated T and B lymphocytes and myeloid cells. However, little is known about the microanatomical distribution of PD-1 in lymphoid organs. In this study, we performed immunohistochemistry using monoclonal antibodies against human PD-1. In human tonsils, PD-1 was expressed on most of T cells and a small subset of centrocytes in the light zone of germinal centers (GCs), where clonal selection of centrocytes takes place. These results suggest that PD-1 may play an important role in GC reaction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Animals
  • Antibodies, Monoclonal
  • Antigens, CD
  • Antigens, Surface / biosynthesis*
  • Apoptosis Regulatory Proteins
  • B-Lymphocytes / metabolism
  • Cells, Cultured
  • Child
  • Child, Preschool
  • Germinal Center / cytology
  • Germinal Center / metabolism
  • Humans
  • Ki-67 Antigen / metabolism
  • Male
  • Mice
  • Palatine Tonsil / cytology*
  • Palatine Tonsil / metabolism
  • Programmed Cell Death 1 Receptor
  • T-Lymphocytes / metabolism
  • Time Factors
  • Transfection


  • Antibodies, Monoclonal
  • Antigens, CD
  • Antigens, Surface
  • Apoptosis Regulatory Proteins
  • Ki-67 Antigen
  • PDCD1 protein, human
  • Pdcd1 protein, mouse
  • Programmed Cell Death 1 Receptor