Circulating IL-6 and sIL-6R in patients with hepatocellular carcinoma

Ann N Y Acad Sci. 2002 Jun;963:46-52. doi: 10.1111/j.1749-6632.2002.tb04093.x.


Interleukin-6 plays a central role in regulating the immune system, hematopoiesis, and acute phase reaction. It interacts with a receptor complex consisting of a specific ligand-binding protein (IL-6R, gp80) and a signal transduction protein (gp130). In this report, serum levels of IL-6 and a soluble form of the interleukin-6 receptor (sIL-6R) were evaluated in patients with hepatocellular carcinoma. The correlation between IL-6 and sIL-6R values, the stage of hepatocellular carcinoma, and main liver function tests was also studied.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Hepatocellular / blood
  • Carcinoma, Hepatocellular / immunology*
  • Female
  • Humans
  • Interleukin-6 / blood
  • Interleukin-6 / immunology*
  • Liver Neoplasms / blood
  • Liver Neoplasms / immunology*
  • Male
  • Middle Aged
  • Receptors, Interleukin-6 / blood
  • Receptors, Interleukin-6 / immunology*


  • Interleukin-6
  • Receptors, Interleukin-6