From castration-induced apoptosis of prostatic epithelium to the use of apoptotic genes in the treatment of prostate cancer

Ann N Y Acad Sci. 2002 Jun:963:191-203. doi: 10.1111/j.1749-6632.2002.tb04110.x.

Abstract

Current knowledge of the mechanisms regulating androgen-ablation-induced apoptosis is reviewed, and our efforts to develop a system in which genes of the apoptotic pathway are used to induce therapeutic apoptosis in experimental models of prostate cancer are described.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Androgens / deficiency
  • Androgens / physiology
  • Animals
  • Apoptosis* / genetics
  • Castration / adverse effects*
  • Epithelial Cells / pathology
  • Forecasting
  • Humans
  • Male
  • Mitochondria / physiology
  • Models, Animal
  • Prostatic Neoplasms / drug therapy
  • Prostatic Neoplasms / pathology*
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-bcl-2*
  • Rats
  • Receptors, Androgen / physiology
  • bcl-2-Associated X Protein

Substances

  • Androgens
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • Receptors, Androgen
  • bcl-2-Associated X Protein