Effects of weight control and physical activity in cancer prevention: role of endogenous hormone metabolism

Ann N Y Acad Sci. 2002 Jun;963:268-81. doi: 10.1111/j.1749-6632.2002.tb04118.x.

Abstract

Excess body weight and/or lack of physical activity are increasingly recognized as major risk factors for cancer of the colon, breast, endometrium, and prostate. This paper reviews the effects of excess body weight and physical inactivity on endogenous hormone metabolism (insulin, the IGF-I/IGFBP system, and sex steroids) and of endocrine alterations with risk of cancer of the endometrium, breast, prostate, and colon.

MeSH terms

  • Body Weight / physiology*
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / prevention & control
  • Colorectal Neoplasms / metabolism
  • Colorectal Neoplasms / prevention & control
  • Endometrial Neoplasms / metabolism
  • Endometrial Neoplasms / prevention & control
  • Exercise / physiology*
  • Female
  • Gonadal Steroid Hormones / blood
  • Hormones / metabolism*
  • Humans
  • Male
  • Neoplasms / epidemiology
  • Neoplasms / metabolism
  • Neoplasms / prevention & control*
  • Obesity / complications
  • Obesity / metabolism
  • Preventive Medicine
  • Prostatic Neoplasms / metabolism
  • Prostatic Neoplasms / prevention & control
  • Risk Factors

Substances

  • Gonadal Steroid Hormones
  • Hormones