Fibrosis and atrophy in the renal allograft: interim report and new directions

Am J Transplant. 2002 Mar;2(3):203-6. doi: 10.1034/j.1600-6143.2002.20303.x.


The topic of chronic allograft nephropathy/chronic rejection is reviewed, with focus on fibrosing/sclerosing changes and late loss of function in renal allografts. Discussion includes a review of the problem, pathological and clinical findings, and new directions. Emphasis is placed on definition of specific diagnostic entities in these allografts, and identification of ongoing/active processes in this setting that might be amenable to direct intervention. A schema for categorizing these cases is proposed.

Publication types

  • Congress

MeSH terms

  • Atrophy
  • Fibrosis
  • Graft Rejection / pathology
  • Humans
  • Kidney / pathology
  • Kidney Transplantation / pathology*
  • Transplantation, Homologous / pathology
  • Treatment Failure