The FAS-670 polymorphism influences susceptibility to multiple sclerosis

J Neuroimmunol. 2002 Jul;128(1-2):95-100. doi: 10.1016/s0165-5728(02)00163-7.


Several studies have reported a defective Fas function in patients with multiple sclerosis (MS). We were interested whether this could result from a genetically altered Fas regulation. We examined the FAS-670 polymorphism in 382 patients with MS and 206 controls, and found that the carriership of allele FAS-670*G was significantly less frequent in patients than in controls. We found no association between the carriership of FAS-670*G and clinical features. For a subgroup of patients, longitudinal MRI data were available. We observed similar brain and lesion volumes in carriers and noncarriers of FAS-670*G. These data suggest that FAS-670*G decreases the risk of developing MS, but does not affect the course of disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age of Onset
  • Brain / immunology
  • Brain / pathology
  • Brain / physiopathology
  • DNA Mutational Analysis
  • Fas Ligand Protein
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease / genetics*
  • Genetic Testing
  • Humans
  • Interferon-beta / therapeutic use
  • Magnetic Resonance Imaging
  • Male
  • Membrane Glycoproteins / genetics*
  • Membrane Glycoproteins / immunology
  • Middle Aged
  • Multiple Sclerosis / genetics*
  • Multiple Sclerosis / immunology
  • Multiple Sclerosis / physiopathology
  • Polymorphism, Genetic / genetics*
  • Polymorphism, Genetic / immunology
  • Sex Factors
  • fas Receptor / genetics*
  • fas Receptor / immunology


  • FASLG protein, human
  • Fas Ligand Protein
  • Membrane Glycoproteins
  • fas Receptor
  • Interferon-beta