KIAA0202, a human septin family member, interacting with hPFTAIRE1

Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2002 Jul;34(4):520-5.


hPFTAIRE1 is a member of Cdc2-related kinase family localized in cytoplasm. To search its substrates and regulatory proteins, the hPFTAIRE1 was fused to LexA and used as bait to screen a human brain LexA two-hybrid library. In this screening, 7 hPFTAIRE1 interacting proteins, including KIAA0202, were obtained. The interaction between the KIAA0202 and the hPFTAIRE1 was confirmed by using immunoprecipitation. The KIAA0202 is a 508 aa protein and is a member of septin family. The central portion of the KIAA0202 is a GTP-CDC domain, which is conserved among almost all septins. Its C-terminus is a coiled-coil structure and its N-terminus is a variable region. Our results suggest that the KIAA0202 may play important roles in functional regulation of hPFTAIRE1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Brain / metabolism
  • GTP Phosphohydrolases / genetics
  • GTP Phosphohydrolases / metabolism*
  • Humans
  • Membrane Proteins*
  • Molecular Sequence Data
  • Precipitin Tests
  • Protein Binding
  • Protein Kinases / genetics
  • Protein Kinases / metabolism*
  • Septins
  • Sequence Homology, Amino Acid
  • Two-Hybrid System Techniques


  • Membrane Proteins
  • Protein Kinases
  • Pftk1 protein, mouse
  • GTP Phosphohydrolases
  • SEPTIN8 protein, human
  • Septins
  • septin 3