A new clue to the prenatal diagnosis of lobar holoprosencephaly: the abnormal pathway of the anterior cerebral artery crawling under the skull

Ultrasound Obstet Gynecol. 2002 Jun;19(6):605-7. doi: 10.1046/j.1469-0705.2002.00729.x.


We report a case of a 24-week-old fetus with cerebral anomalies suggestive of lobar holoprosencephaly including an unusual course of the anterior cerebral artery on Doppler examination. This abnormal trajectory of the anterior cerebral artery in holoprosencephalic brains has been described by pathologists, neurosurgeons and radiologists but our case indicates that this finding may be a useful adjunct to confirm such a difficult diagnosis prenatally.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anterior Cerebral Artery / diagnostic imaging
  • Anterior Cerebral Artery / embryology*
  • Female
  • Holoprosencephaly / diagnostic imaging*
  • Humans
  • Pregnancy
  • Ultrasonography, Doppler
  • Ultrasonography, Prenatal*