Diabetic muscle infarction after simultaneous pancreas-kidney transplant

Clin Transplant. 2002 Aug;16(4):295-300. doi: 10.1034/j.1399-0012.2002.01151.x.


Diabetic muscle infarction (DMI) is a rare entity that occurs in patients with long-standing type 1 insulin dependent diabetes mellitus (IDDM). We describe DMI occurring on an average of 5 months after SPK in four patients with IDDM and end stage renal disease (ESRD). These patients had evidence of other long-term diabetic complications including retinopathy and neuropathy, as well as microangiopathy and hypercoagulability, both of which are pre-disposing factors for DMI. The etiology of DMI is not well understood. Despite establishment of normoglycemia after kidney-pancreas transplantation, DMI may occur as a result of tissue damage/fragility secondary to the pre-existing long-term labile glycemic control and hypertension. This may be exacerbated by the pro-coagulant effects of the calcineurin-inhibitors and the use of steroids as part of the immunosuppressive regimen.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Causality
  • Diabetes Mellitus, Type 1 / complications
  • Diabetes Mellitus, Type 1 / surgery
  • Diabetic Neuropathies / complications
  • Diabetic Retinopathy / complications
  • Female
  • Humans
  • Immunosuppressive Agents / adverse effects
  • Infarction / etiology*
  • Kidney Failure, Chronic / complications
  • Kidney Failure, Chronic / surgery
  • Kidney Transplantation*
  • Muscle, Skeletal / blood supply*
  • Pancreas Transplantation*


  • Immunosuppressive Agents