Hyperlipidaemia and venous thromboembolism in patients lacking thrombophilic risk factors

Br J Haematol. 2002 Jul;118(1):255-9. doi: 10.1046/j.1365-2141.2002.03563.x.


To ascertain the potential contribution of serum lipids to the development of deep vein thrombosis (DVT), a case-control study was conducted in 143 DVT patients lacking thrombophilic risk factors and in 194 age- and sex-matched controls. DVT patients showed significantly higher body mass indices (BMI), and triglyceride levels than did controls (P < 0.001 and P = 0.045 respectively). Using multivariate analysis, BMI was the only variable which remained statistically different, thus the risk of DVT was associated with obesity (odds ratio = 2.49). These results were confirmed when additional control for fibrinogen and plasminogen activator inhibitor type 1 (PAI-1) was carried out in a subgroup of cases and controls. When idiopathic (n = 39) and secondary (n = 104) patients with DVT were compared, the former showed a higher mean age, a higher proportion of men, and higher cholesterol levels. Age, sex and total cholesterol were statistically different by multivariate analysis. After age was dichotomized as >or= 50 years and cholesterol >or= 5.69 mmol/l, all three variables constituted independent risk factors for idiopathic DVT, with odds ratios of 2.73 for ages >or= 50 years; 3.72 for men and 2.67 for cholesterolaemia >or= 5.69 mmol/l. Obesity thus constitutes an independent risk factor for DVT, possibly in part mediated through triglyceride, fibrinogen and PAI-1 effects on haemostasis. In addition, cholesterolaemia levels of >or= 5.69 mmol/l constitute an independent risk factor for idiopathic DVT.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Body Mass Index
  • Case-Control Studies
  • Cholesterol / blood
  • Female
  • Fibrinogen / analysis
  • Humans
  • Hyperlipidemias / complications*
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Plasminogen Activator Inhibitor 1 / analysis
  • Pulmonary Embolism / blood*
  • Risk Factors
  • Sex Factors
  • Triglycerides / blood
  • Venous Thrombosis / blood*


  • Plasminogen Activator Inhibitor 1
  • Triglycerides
  • Fibrinogen
  • Cholesterol