Cell movements during gastrulation: snail dependent and independent pathways

Curr Opin Genet Dev. 2002 Aug;12(4):423-9. doi: 10.1016/s0959-437x(02)00320-9.

Abstract

The morphogenetic process of gastrulation requires multiple inputs and intricate coordination. Genetic analyses demonstrate critical roles of vertebrate and invertebrate Snail proteins in this process. Together with other regulatory molecules including Wnt and BMP, the Snail pathways specify cell fate and reorganize cellular machineries to coordinate morphological changes and cell movements during gastrulation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adherens Junctions
  • Animals
  • Caenorhabditis elegans / embryology
  • Cell Division / physiology
  • Cell Movement / physiology*
  • DNA-Binding Proteins / physiology*
  • Drosophila / embryology
  • Drosophila Proteins / physiology
  • Gastrula / cytology*
  • Gene Expression Regulation, Developmental / physiology
  • Mice
  • Proto-Oncogene Proteins / physiology
  • Receptors, Cell Surface / physiology
  • Signal Transduction / physiology
  • Snail Family Transcription Factors
  • Toll-Like Receptors
  • Transcription Factors / physiology*
  • Wnt Proteins
  • Zebrafish Proteins*
  • rho GTP-Binding Proteins / physiology

Substances

  • DNA-Binding Proteins
  • Drosophila Proteins
  • Proto-Oncogene Proteins
  • Receptors, Cell Surface
  • Snail Family Transcription Factors
  • Tl protein, Drosophila
  • Toll-Like Receptors
  • Transcription Factors
  • Wnt Proteins
  • Zebrafish Proteins
  • sna protein, Drosophila
  • rho GTP-Binding Proteins