Phox2 genes - from patterning to connectivity

Curr Opin Genet Dev. 2002 Aug;12(4):435-40. doi: 10.1016/s0959-437x(02)00322-2.


In the developing brain, many transcription factors are expressed in complex patterns and dynamics, and drive the differentiation of many classes of neurons. How does the spatio-temporal landscape of transcription factor expression map onto the bewildering variety of neuronal types, and, for each of them, the variety of developmental stages they go through? In other words, what is the logic in the transcriptional control of neuronal differentiation? Here, we review what recent work on the two neuronal-type-specific transcription factors Phox2a and Phox2b has contributed to our understanding of this broad question.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Body Patterning
  • Brain / cytology
  • Brain / embryology*
  • Cell Differentiation / physiology
  • Homeodomain Proteins / genetics*
  • Homeodomain Proteins / physiology
  • Humans
  • Nerve Tissue Proteins
  • Neurons / physiology
  • Transcription Factors / genetics*
  • Transcription Factors / physiology


  • Homeodomain Proteins
  • NBPhox protein
  • Nerve Tissue Proteins
  • PHOX2A protein, human
  • Transcription Factors