Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators

Curr Opin Genet Dev. 2002 Aug;12(4):441-6. doi: 10.1016/s0959-437x(02)00323-4.


SOX transcription factors perform a remarkable variety of important roles in vertebrate development, either activating or repressing specific target genes through interaction with different partner proteins. Surprisingly, these interactions are often mediated by the conserved, DNA-binding HMG domain, raising questions as to how each factor's specificity is generated. We propose a model whereby non-HMG domains may influence partner protein selection and/or binding stability.

Publication types

  • Review

MeSH terms

  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / physiology*
  • High Mobility Group Proteins / chemistry
  • Protein Structure, Tertiary
  • Transcription Factors / chemistry
  • Transcription Factors / physiology*


  • DNA-Binding Proteins
  • High Mobility Group Proteins
  • Transcription Factors