Cell lineage specification in the nervous system

Curr Opin Genet Dev. 2002 Aug;12(4):473-7. doi: 10.1016/s0959-437x(02)00328-3.


Nervous system development requires the specification of numerous neural stem cells. Subsequently these stem cells divide in a spatially and temporally controlled manner to generate the diverse cell types found in the different layers of the nervous system. Lineage specification is brought about by transcriptional regulators, which often act as transcriptional repressors.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation / physiology*
  • Drosophila / embryology
  • Gene Expression Regulation, Developmental / physiology
  • Mice
  • Nervous System / embryology*
  • Stem Cells / physiology*
  • Transcription Factors / physiology
  • Transcription, Genetic / physiology


  • Transcription Factors