Developmental expression of cytochrome CYP26B1 (P450RAI-2) in human cephalic tissues

Brain Res Dev Brain Res. 2002 Jun 30;136(2):175-8. doi: 10.1016/s0165-3806(02)00305-x.

Abstract

Expression levels of cytochrome CYP26B1, which is involved in the specific all-trans-RA inactivation, were evaluated in human cephalic tissues at gestational days 57-110 and exhibited values approximately 10-fold higher than later gestational days 112-224 and adult tissues. CYP26B1 mRNA levels in the adult cerebellum were approximately 2-fold higher than in the adult whole brain tissue. Considered together, these data suggest a unique role for CYP26B1 during human brain development.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Brain / cytology
  • Brain / embryology
  • Brain / enzymology*
  • Cell Differentiation / physiology*
  • Cerebellum / cytology
  • Cerebellum / embryology
  • Cerebellum / enzymology
  • Cytochrome P-450 Enzyme System / genetics*
  • Embryo, Mammalian / cytology
  • Embryo, Mammalian / embryology
  • Embryo, Mammalian / enzymology*
  • Fetus / cytology
  • Fetus / embryology
  • Fetus / enzymology*
  • Gene Expression Regulation, Developmental / physiology
  • Gene Expression Regulation, Enzymologic / physiology
  • Humans
  • RNA, Messenger / metabolism*
  • Retinoic Acid 4-Hydroxylase
  • Tretinoin / metabolism*

Substances

  • RNA, Messenger
  • Tretinoin
  • Cytochrome P-450 Enzyme System
  • Retinoic Acid 4-Hydroxylase