Abstract
Expression levels of cytochrome CYP26B1, which is involved in the specific all-trans-RA inactivation, were evaluated in human cephalic tissues at gestational days 57-110 and exhibited values approximately 10-fold higher than later gestational days 112-224 and adult tissues. CYP26B1 mRNA levels in the adult cerebellum were approximately 2-fold higher than in the adult whole brain tissue. Considered together, these data suggest a unique role for CYP26B1 during human brain development.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Brain / cytology
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Brain / embryology
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Brain / enzymology*
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Cell Differentiation / physiology*
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Cerebellum / cytology
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Cerebellum / embryology
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Cerebellum / enzymology
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Cytochrome P-450 Enzyme System / genetics*
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Embryo, Mammalian / cytology
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Embryo, Mammalian / embryology
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Embryo, Mammalian / enzymology*
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Fetus / cytology
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Fetus / embryology
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Fetus / enzymology*
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Gene Expression Regulation, Developmental / physiology
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Gene Expression Regulation, Enzymologic / physiology
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Humans
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RNA, Messenger / metabolism*
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Retinoic Acid 4-Hydroxylase
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Tretinoin / metabolism*
Substances
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RNA, Messenger
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Tretinoin
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Cytochrome P-450 Enzyme System
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Retinoic Acid 4-Hydroxylase