Long-term benefits of biventricular pacing in congestive heart failure: results from the MUltisite STimulation in cardiomyopathy (MUSTIC) study

J Am Coll Cardiol. 2002 Jul 3;40(1):111-8. doi: 10.1016/s0735-1097(02)01932-0.


Objectives: The main objective of this study was to assess if the benefits of biventricular (BiV) pacing observed during the crossover phase were sustained over 12 months.

Background: MUltisite STimulation In Cardiomyopathies (MUSTIC) is a randomized controlled study intended to evaluate the effects of BiV pacing in patients with New York Heart Association (NYHA) class III heart failure and intraventricular conduction delay.

Methods: Of 131 patients included, 42/67 in sinus rhythm (SR) and 33/64 in atrial fibrillation (AF) were followed up longitudinally at 9 and 12 months by 6-min walked distance, peak oxygen uptake (peak VO(2)), quality of life by the Minnesota score, NYHA class, echocardiography, and left ventricular ejection fraction by radionuclide technique.

Results: At 12 months, all SR and 88% of AF patients were programmed to BiV pacing. Compared with baseline, the 6-min walked distance increased by 20% (SR) (p = 0.0001) and 17% (AF) (p = 0.004); the peak VO(2) by 11% (SR) and 9% (AF); quality of life improved by 36% (SR) (p = 0.0001) and 32% (AF) (p = 0.002); NYHA class improved by 25% (SR) (p = 0.0001) and 27% (AF) (p = 0.0001). The ejection fraction improved by 5% (SR) and 4% (AF). Mitral regurgitation decreased by 45% (SR) and 50% (AF).

Conclusions: The clinical benefits of BiV pacing appeared to be significantly maintained over a 12-month follow-up period.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Atrial Fibrillation / therapy
  • Cardiac Pacing, Artificial / methods*
  • Case-Control Studies
  • Cross-Over Studies
  • Electrocardiography
  • Exercise Tolerance
  • Female
  • Follow-Up Studies
  • Heart Failure / therapy*
  • Hospitalization / statistics & numerical data
  • Humans
  • Male
  • Middle Aged
  • Pacemaker, Artificial
  • Quality of Life
  • Single-Blind Method
  • Time Factors